Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 9 Reviews
8.7
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Milk Thistle Phospholipid Proprietary BlendMilk thistle extract (fruit) [providing 480 mg silymarin, 180 mg silybin, 48 mg isosilybin A and isosilybin B], phospholipids
760 mg
**
SILIPHOS® phytosome milk thistle extract (fruit) [providing 47.52 mg silybin]
160 mg
**
Top Medical Research Studies
8
We aimed to explore how flavonolignans from silybum marianum, specifically silybin, silychristin, and silydianin, affect blood clotting through the COX pathway in platelets. Our methods involved analyzing platelet aggregation and the formation of COX pathway metabolites.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
Read More
7
Silibinin shows promise for COVID-19
We explored silibinin from Silybum marianum as a potential treatment against SARS-CoV-2, focusing on its anti-inflammatory and anticoagulant effects. Through in silico analysis, we found that silibinin effectively binds to key viral proteins, suggesting it could inhibit the virus's entry and replication.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Read More
Most Useful Reviews
9
Enhanced liver health
97 people found this helpful
One of the best liver medications for both prevention and treatment! I purchase this product for my mother, who has chronic viral hepatitis, as liver support is crucial for her. As you know, milk thistle is the leading herb for liver health, although its primary compound, silybin, is poorly soluble in water, hindering absorption. The phosphatidylcholine encapsulates silybin, allowing better absorption into the blood, increasing its bioavailability by tenfold. This results in improved protection of liver cells, detoxification, and stimulation of healthy cell growth. Mum is pleased with this product's effectiveness, and her analyses confirm it; she takes it at night, as liver bioactivity peaks between 1-3 a.m.
Read More
9
Royal gift from nature
95 people found this helpful
On iHerb, this is the richest syphonate for the liver! After searching for the most effective liposomal silybin, I found this product containing the highest amount of silybin per capsule, essential for liver health. I suffer from fatty hepatosis and take one capsule nightly. I combine it with liver-supporting mushrooms for comprehensive care. Now, I use only liposomal milk thistle preparations, which enhance absorption by ten times. The effects of silymarin on the liver are remarkable: restoring damaged cells, detoxifying, preventing fibrosis, and even clearing skin issues. Truly, a royal gift from nature!
Read More
9
Liver function normalised
7 people found this helpful
I had fatty liver and was advised to exercise and maintain a healthy diet. Unfortunately, I struggled to follow through. I took these tablets for months, and my last blood test showed my liver has returned to normal. I continue to take them, hoping to maintain my liver function.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
We aimed to explore how flavonolignans from silybum marianum, specifically silybin, silychristin, and silydianin, affect blood clotting through the COX pathway in platelets. Our methods involved analyzing platelet aggregation and the formation of COX pathway metabolites.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
Read More
7
Silibinin shows promise for COVID-19
We explored silibinin from Silybum marianum as a potential treatment against SARS-CoV-2, focusing on its anti-inflammatory and anticoagulant effects. Through in silico analysis, we found that silibinin effectively binds to key viral proteins, suggesting it could inhibit the virus's entry and replication.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Enhanced liver health
97 people found this helpful
One of the best liver medications for both prevention and treatment! I purchase this product for my mother, who has chronic viral hepatitis, as liver support is crucial for her. As you know, milk thistle is the leading herb for liver health, although its primary compound, silybin, is poorly soluble in water, hindering absorption. The phosphatidylcholine encapsulates silybin, allowing better absorption into the blood, increasing its bioavailability by tenfold. This results in improved protection of liver cells, detoxification, and stimulation of healthy cell growth. Mum is pleased with this product's effectiveness, and her analyses confirm it; she takes it at night, as liver bioactivity peaks between 1-3 a.m.
Read More
9
Royal gift from nature
95 people found this helpful
On iHerb, this is the richest syphonate for the liver! After searching for the most effective liposomal silybin, I found this product containing the highest amount of silybin per capsule, essential for liver health. I suffer from fatty hepatosis and take one capsule nightly. I combine it with liver-supporting mushrooms for comprehensive care. Now, I use only liposomal milk thistle preparations, which enhance absorption by ten times. The effects of silymarin on the liver are remarkable: restoring damaged cells, detoxifying, preventing fibrosis, and even clearing skin issues. Truly, a royal gift from nature!
Read More
9
Liver function normalised
7 people found this helpful
I had fatty liver and was advised to exercise and maintain a healthy diet. Unfortunately, I struggled to follow through. I took these tablets for months, and my last blood test showed my liver has returned to normal. I continue to take them, hoping to maintain my liver function.
Read More
10
Impressive blood results
2 people found this helpful
Life Extension offers such clean ingredients, which is why I prefer this brand. After my last blood test, my liver was in such good condition that my doctor was impressed by the Life Extension milk thistle. I wholeheartedly recommend it!
Read More
7.5
Decreased liver indices
2 people found this helpful
The effects of this product are remarkable. After two months of use, my blood and liver indices have significantly decreased.
Read More
Frequently Asked Questions
7.5
Decreased liver indices
2 people found this helpful
The effects of this product are remarkable. After two months of use, my blood and liver indices have significantly decreased.
7.5
Grandmother's recovery
I bought this for my grandmother; her condition has improved significantly over the second course. Overall, her condition and blood markers have definitely improved over the past 3-4 months.
9
Liver function normalised
7 people found this helpful
I had fatty liver and was advised to exercise and maintain a healthy diet. Unfortunately, I struggled to follow through. I took these tablets for months, and my last blood test showed my liver has returned to normal. I continue to take them, hoping to maintain my liver function.
9
Enhanced liver health
97 people found this helpful
One of the best liver medications for both prevention and treatment! I purchase this product for my mother, who has chronic viral hepatitis, as liver support is crucial for her. As you know, milk thistle is the leading herb for liver health, although its primary compound, silybin, is poorly soluble in water, hindering absorption. The phosphatidylcholine encapsulates silybin, allowing better absorption into the blood, increasing its bioavailability by tenfold. This results in improved protection of liver cells, detoxification, and stimulation of healthy cell growth. Mum is pleased with this product's effectiveness, and her analyses confirm it; she takes it at night, as liver bioactivity peaks between 1-3 a.m.
7.5
Reduced hangovers
3 people found this helpful
This product has significantly reduced my hangovers. I’ve taken it for about a year; I originally bought it for liver health without much thought. I noticed my fatigue has lessened, allowing me to wake up early feeling refreshed. Notably, my hangover symptoms have virtually disappeared, providing relief after nights out. Its long-term use seems to enhance these benefits.
8
We aimed to explore how flavonolignans from silybum marianum, specifically silybin, silychristin, and silydianin, affect blood clotting through the COX pathway in platelets. Our methods involved analyzing platelet aggregation and the formation of COX pathway metabolites.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
7
Silibinin shows promise for COVID-19
We explored silibinin from Silybum marianum as a potential treatment against SARS-CoV-2, focusing on its anti-inflammatory and anticoagulant effects. Through in silico analysis, we found that silibinin effectively binds to key viral proteins, suggesting it could inhibit the virus's entry and replication.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
References
- Speciale A, MuscarĂ C, Molonia MS, Cimino F, Saija A, et al. Silibinin as potential tool against SARS-Cov-2: In silico spike receptor-binding domain and main protease molecular docking analysis, and in vitro endothelial protective effects. Phytother Res. 2021;35:4616. doi:10.1002/ptr.7107
- Bijak M, Saluk-Bijak J. Flavonolignans inhibit the arachidonic acid pathway in blood platelets. BMC Complement Altern Med. 2017;17:396. doi:10.1186/s12906-017-1897-7
